XBioSiP: A Methodology for Approximate Bio-Signal Processing at the Edge

Bio-signals exhibit high redundancy, and the algorithms for their processing are inherently error resilient. This property can be leveraged to improve the energy-efficiency of IoT-Edge (wearables) through the emerging trend of approximate computing. This paper presents XBioSiP, a novel methodology for approximate bio-signal processing that employs two quality evaluation stages, during the pre-processing and bio-signal processing stages, to determine the approximation parameters. It thereby achieves high energy savings while satisfying the user-determined quality constraint. Our methodology achieves, up to 19x and 22x reduction in the energy consumption of a QRS peak detection algorithm for 0% and <1% loss in peak detection accuracy, respectively.Comment: Accepted for publication at the Design Automation Conference 2019 (DAC'19), Las Vegas, Nevada, US

BoundaryCAM: A Boundary-based Refinement Framework for Weakly Supervised Semantic Segmentation of Medical Images

Weakly Supervised Semantic Segmentation (WSSS) with only image-level supervision is a promising approach to deal with the need for Segmentation networks, especially for generating a large number of pixel-wise masks in a given dataset. However, most state-of-the-art image-level WSSS techniques lack an understanding of the geometric features embedded in the images since the network cannot derive any object boundary information from just image-level labels. We define a boundary here as the line separating an object and its background, or two different objects. To address this drawback, we propose our novel BoundaryCAM framework, which deploys state-of-the-art class activation maps combined with various post-processing techniques in order to achieve fine-grained higher-accuracy segmentation masks. To achieve this, we investigate a state-of-the-art unsupervised semantic segmentation network that can be used to construct a boundary map, which enables BoundaryCAM to predict object locations with sharper boundaries. By applying our method to WSSS predictions, we were able to achieve up to 10% improvements even to the benefit of the current state-of-the-art WSSS methods for medical imaging. The framework is open-source and accessible online at https://github.com/bharathprabakaran/BoundaryCAM

Image Label based Semantic Segmentation Framework using Object Perimeters

Achieving high-quality semantic segmentation predictions using only image-level labels enables a new level of real-world applicability. Although state-of-the-art networks deliver reliable predictions, the amount of handcrafted pixel-wise annotations to enable these results are not feasible in many real-world applications. Hence, several works have already targeted this bottleneck, using classifier-based networks like Class Activation Maps (CAMs) as a base. Addressing CAM's weaknesses of fuzzy borders and incomplete predictions, state-of-the-art approaches rely only on adding regulations to the classifier loss or using pixel-similarity-based refinement after the fact. We propose a framework that introduces an additional module using object perimeters for improved saliency. We define object perimeter information as the line separating the object and background. Our new PerimeterFit module will be applied to pre-refine the CAM predictions before using the pixel-similarity-based network. In this way, our PerimeterFit increases the quality of the CAM prediction while simultaneously improving the false negative rate. We investigated a wide range of state-of-the-art unsupervised semantic segmentation networks and edge detection techniques to create useful perimeter maps, which enable our framework to predict object locations with sharper perimeters. We achieved up to 1.5\% improvement over frameworks without our PerimeterFit module. We conduct an exhaustive analysis to illustrate that our framework enhances existing state-of-the-art frameworks for image-level-based semantic segmentation. The framework is open-source and accessible online at https://github.com/ErikOstrowski/Perimeter-based-Semantic-Segmentation

FPUS23: An Ultrasound Fetus Phantom Dataset with Deep Neural Network Evaluations for Fetus Orientations, Fetal Planes, and Anatomical Features

Ultrasound imaging is one of the most prominent technologies to evaluate the growth, progression, and overall health of a fetus during its gestation. However, the interpretation of the data obtained from such studies is best left to expert physicians and technicians who are trained and well-versed in analyzing such images. To improve the clinical workflow and potentially develop an at-home ultrasound-based fetal monitoring platform, we present a novel fetus phantom ultrasound dataset, FPUS23, which can be used to identify (1) the correct diagnostic planes for estimating fetal biometric values, (2) fetus orientation, (3) their anatomical features, and (4) bounding boxes of the fetus phantom anatomies at 23 weeks gestation. The entire dataset is composed of 15,728 images, which are used to train four different Deep Neural Network models, built upon a ResNet34 backbone, for detecting aforementioned fetus features and use-cases. We have also evaluated the models trained using our FPUS23 dataset, to show that the information learned by these models can be used to substantially increase the accuracy on real-world ultrasound fetus datasets. We make the FPUS23 dataset and the pre-trained models publicly accessible at https://github.com/bharathprabakaran/FPUS23, which will further facilitate future research on fetal ultrasound imaging and analysis

UnbiasedNets: A Dataset Diversification Framework for Robustness Bias Alleviation in Neural Networks

Performance of trained neural network (NN) models, in terms of testing accuracy, has improved remarkably over the past several years, especially with the advent of deep learning. However, even the most accurate NNs can be biased toward a specific output classification due to the inherent bias in the available training datasets, which may propagate to the real-world implementations. This paper deals with the robustness bias, i.e., the bias exhibited by the trained NN by having a significantly large robustness to noise for a certain output class, as compared to the remaining output classes. The bias is shown to result from imbalanced datasets, i.e., the datasets where all output classes are not equally represented. Towards this, we propose the UnbiasedNets framework, which leverages K-means clustering and the NN's noise tolerance to diversify the given training dataset, even from relatively smaller datasets. This generates balanced datasets and reduces the bias within the datasets themselves. To the best of our knowledge, this is the first framework catering to the robustness bias problem in NNs. We use real-world datasets to demonstrate the efficacy of the UnbiasedNets for data diversification, in case of both binary and multi-label classifiers. The results are compared to well-known tools aimed at generating balanced datasets, and illustrate how existing works have limited success while addressing the robustness bias. In contrast, UnbiasedNets provides a notable improvement over existing works, while even reducing the robustness bias significantly in some cases, as observed by comparing the NNs trained on the diversified and original datasets.Comment: Springer Machine Learning 202

EMAP: A Cloud-Edge Hybrid Framework for EEG Monitoring and Cross-Correlation Based Real-time Anomaly Prediction

State-of-the-art techniques for detecting, or predicting, neurological disorders (1) focus on predicting each disorder individually, and are (2) computationally expensive, leading to a delay that can potentially render the prediction useless, especially in critical events. Towards this, we present a real-time two-tiered framework called EMAP, which cross-correlates the input with all the EEG signals in our mega-database (a combination of multiple EEG datasets) at the cloud, while tracking the signal in real-time at the edge, to predict the occurrence of a neurological anomaly. Using the proposed framework, we have demonstrated a prediction accuracy of up to 94% for the three different anomalies that we have tested.Comment: Accepted for Publication at the 57th Design Automation Conference (DAC), July 2020, San Francisco, CA, US

Xel-FPGAs: An End-to-End Automated Exploration Framework for Approximate Accelerators in FPGA-Based Systems

Generation and exploration of approximate circuits and accelerators has been a prominent research domain to achieve energy-efficiency and/or performance improvements. This research has predominantly focused on ASICs, while not achieving similar gains when deployed for FPGA-based accelerator systems, due to the inherent architectural differences between the two. In this work, we propose a novel framework, Xel-FPGAs, which leverages statistical or machine learning models to effectively explore the architecture-space of state-of-the-art ASIC-based approximate circuits to cater them for FPGA-based systems given a simple RTL description of the target application. We have also evaluated the scalability of our framework on a multi-stage application using a hierarchical search strategy. The Xel-FPGAs framework is capable of reducing the exploration time by up to 95%, when compared to the default synthesis, place, and route approaches, while identifying an improved set of Pareto-optimal designs for a given application, when compared to the state-of-the-art. The complete framework is open-source and available online at https://github.com/ehw-fit/xel-fpgas.Comment: Accepted for publication at the 42nd International Conference on Computer-Aided Design (ICCAD), November 2023, San Francisco, CA, US

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Architectural-Space Exploration of Heterogeneous Reliability and Checkpointing Modes for Out-of-Order Superscalar Processors

State-of-the-art reliability techniques and mechanisms deploy full-scale redundancy, like double or triple modular redundancy (DMR, TMR), on different layers of the computing stack to detect and/or correct such transient faults. However, the techniques relying on full-scale redundancy incur significant area, performance, and/or power overheads, which might not always be feasible/practical due to system constraints such as deadlines and available power budget for the full chip (or a processor core). In this work, we propose a novel design methodology to generate and explore the architectural-space of heterogeneous reliability modes for out-of-order superscalar multi-core processors. These heterogeneous modes enable varying reliability and power/area trade-offs, from which an optimal configuration can be chosen at run time to meet the reliability requirements of a given system while reducing the corresponding power overheads (or solving the inverse problem, i.e., maximizing the reliability under a given power constraint). Our experimental results show that a pareto-optimal heterogeneous reliability mode reduces the core vulnerability by 87%, on average, across multiple application workloads, with area and power overheads of 10% and 43%, respectively. To further enhance the design space of heterogeneous reliability modes, we investigate the effectiveness of combining different processor state compression techniques like Distributed Multi-threaded Checkpointing (DMTCP), Hash-based Incremental Checkpointing (HBICT) and GNU zip, such that the correct processor state can be recovered once a fault is detected. We reduced the checkpoint sizes by a factor of ~6× using a unique combination of different state compression techniques